type I interferon – Communicable Diseases Research

Production of single-cycle infectious SARS-CoV-2 through a trans-complemented replicon

Article

Published on 2022-12-012022-11-16
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 치료기술,

Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2

Article

Published on 2022-12-012022-11-16
Journal: Biochemical Genetics
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Analysis applied Bioinformatics analysis biological process Biomarker Brain caused component Cytoscape software database dataset DEGs differentially expressed gene direct infection down-regulated gene enrichment analysis function Gene Expression Omnibus gene expression profile Gene ontology Genes GEO GraphPad Prism software High-throughput sequencing hub genes Human Human iPSC-cardiomyocytes identification infected with SARS-CoV-2 intestine KEGG kidney Kyoto Ligand liver Lung injury mechanisms myocardial injury organ pathway Pathways PPI PPI network protein-protein interaction R software receptor Research respiratory respiratory symptom SARS-CoV-2 SARS-CoV-2. screened sequencing data signaling pathway single-stranded RNA virus statistical analysis statistically significant TNF signaling Type type I interferon up-regulated was obtained was performed website
[DOI] 10.1007/s10528-022-10206-7 PMC 바로가기

More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitro

Article

Published on 2022-11-012022-11-15
Journal: Virus research
[Category] SARS, 치료법, 치료제,

[키워드] ACE2 receptor Analysis Antiviral antiviral genes antiviral response antiviral therapy can be used Cell cell line cells Combination competent Complete coronavirus Coronavirus replication CXCL10 cytidylic acid double-stranded expand fibroblast Gene Expression HCoV-229E HCoV-NL63 help Human human coronavirus human coronaviruses human lung IFN IFNs IFNβ in vitro increase in inducer Infection inhibit innate immune interferons ISG15 limit MERS-CoV Nanoparticles Pathogens Poly I:C. post infection PROTECT provided required SARS-CoV-2 SARS-CoV-2 pandemic stimulate translated Treatment Type I IFN type I interferon virus production were infected while
[DOI] 10.1016/j.virusres.2022.198925 PMC 바로가기

Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling Pathway

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum
[Category] COVID19(2023년), SARS, 치료제,

[키워드] abrogate activated addition bind binding biological significance cellular processe complex disrupt DNA Epigenetic Evidence expression favor Gene Expression HDAC2 Host host antiviral response IFN response IFN signaling pathway IFN-stimulated genes IFNβ IL-1β IL-6 immune response gene inhibit inhibition inhibitory interact Interaction interferons involved IRF3 nsp5 over Pathogenesis pathway promote promoter promoters protease Protease activity protein interaction protein-protein interactions reduce Regulation Replication repress required RNA SARS-CoV-2 SARS-CoV-2 protein Signaling signaling pathway significantly subset Type Type I IFN type I IFN signaling. type I interferon viral infection viral infections Viral protein virus
[DOI] 10.1128/spectrum.02322-22 PMC 바로가기

A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants

Article

Published on 2022-10-062022-11-16
Journal: Cell Stem Cell
[Category] COVID19(2023년), SARS, 변종,

Autoantibodies against apolipoprotein A-1 after COVID-19 predict symptoms persistence

Article

Published on 2022-10-012022-11-15
Journal: European Journal of Clinical Investigation
[Category] COVID19(2023년), SARS, 진단, 치료제,

[키워드] AAA1 Accuracy adjusted age and gender analysis anti-apolipoprotein A-1 autoantibodies anti-SARS-CoV-2 association Auto-antibodies contribute correlation COVID-19 COVID-19 symptom declined determine disease severity hospital human monocyte-derived macrophage IFN-α IFN-γ IgG in vitro induce Inflammatory response logistic regression model Long COVID-19 neurological Odds ratio over Participants persistence persistent predict predicted prognostic remained respiratory symptom respiratory symptoms risk stratification ROC Curve SARS-COV-2 infection serology Symptom Symptoms symptoms persistence Trigger type I interferon type I interferon response. were assessed were used with COVID-19 without affecting
[DOI] 10.1111/eci.13818 PMC 바로가기

Identification of serum metabolites enhancing inflammatory responses in COVID-19

Article

Published on 2022-10-012022-11-15
Journal: Science China. Life sciences
[Category] COVID19(2023년), SARS, 치료제,

[키워드] activate Activation acute respiratory syndrome Administered agmatine alleviate Antiviral caused changed characterized circulating metabolite coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients cytokine production drug Effect effector elevated elicit embryonic exhibiting fibroblast identification IFNs IL-6 IL-6 level Inflammation Inflammatory cytokine Inflammatory response interferon regulatory factor interferons IRFs macrophages metabolite metabolites metabolites. metabolome mice molecular mechanism NF-κB NF-κB pathway Proinflammatory cytokine putrescine responsible resulting SARS-CoV-2 serum severity significantly stages strong immune response systemic inflammatory responses Tandem mass spectrometry tested the disease TNF type I interferon underlie wildtype
[DOI] 10.1007/s11427-021-2099-7 PMC 바로가기

Friend or foe: RIG- I like receptors and diseases

Article

Published on 2022-10-012022-11-15
Journal: Autoimmunity reviews
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

Mechanisms of host type I interferon response modulation by the nucleocapsid proteins of alpha- and betacoronaviruses

알파 및 베타 코로나바이러스의 뉴클레오캡시드 단백질에 의한 숙주 유형 I 인터페론 반응 조절 메커니즘

Review

Published on 2022-10-012022-09-11
Journal: Archives of Virology
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alpha animals Antiviral antiviral responses betacoronavirus cause coronavirus Coronavirus infections COVID-19 pandemic Critical diarrhea epidemic diarrhea facilitate Fatality rate function genomic RNA Health Host Human humans initial innate immune response involved knowledge modulate modulation Neonatal nucleocapsid protein Nucleocapsid proteins PEDV Replication responses responsible SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown Signaling type I interferon viral genomic RNA Viral RNA virions virus Virus-host interactions
[DOI] 10.1007/s00705-022-05513-8 PMC 바로가기 [Article Type] Review

Comparative Upper Respiratory Tract Transcriptomic Profiling Reveals a Potential Role of Early Activation of Interferon Pathway in Severe COVID-19

Article

Published on 2022-10-012022-11-15
Journal: Viruses
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

[키워드] Acute respiratory infection Comparative Coronavirus disease 2019 COVID-19 COVID-19 negative COVID-19 patient COVID-19 patients death driving evaluated Genes Host transcriptional response host-pathogen interactions IFN-I IFN-I response Inflammation initial symptom interferon involved ISG ISGs lung mechanism Mild OAS Potential Profiling progression respiratory Respiratory failure RNA-Seq RNA-sequencing role SARS-CoV-2 severe COVID-19 patient severe COVID-19 patients severe symptom stimulated symptomatic patient the disease tract type I interferon upper upper respiratory tract upregulated viral infection Viral infection. Viral load
[DOI] 10.3390/v14102182 PMC 바로가기